Wls modulates Wnt signaling activity vascular development in the vertebrate pancreas.pdf embryonic lung. Epithelial Wls activity is necessary for respiratory epithelial cell differentiation. Mesenchymal Wls signaling is not essential for early lung morphogenesis.
Wls-mediated secretion of epithelial Wnts promotes pulmonary vascular development. Wls is expressed in developing lung, wherein Wnt signaling is necessary for pulmonary morphogenesis. We hypothesize that Wls plays a critical role in modulating Wnt signaling during lung development and therefore affects processes critical for pulmonary morphogenesis. In the lungs of these mice, VEGF and Tie2-angiopoietin signaling pathways, which mediate vascular development, were downregulated from early stages of development. Wnt5a to regulate pulmonary vascular development.
Wnt ligand activities critical for pulmonary vascular differentiation and peripheral lung morphogenesis. These studies provide a new framework for understanding the molecular mechanisms underlying normal pulmonary vasculature formation and the dysmorphic pulmonary vasculature development associated with congenital lung disease. From a structural standpoint, living systems exhibit a hierarchical pattern of organization in which structures are nested within one another. In this study, the hypothesis is put forward that such a principle is particularly apparent in many morphological and developmental aspects of the vascular system.