Monkshood is notorious for its toxic properties. Aconitine is a Shanbhag pharmacology book pdf free download-norditerpenoid, based on its presence of this C18 carbonaconitum.
Aconitine is very toxic due to several reactive groups. These proteins are highly selective for sodium ions. 2 on the alpha-subunit of the channel protein. This binding results in a sodium-ion channel that stays open longer.
Aconitine suppresses the conformational change in the sodium-ion channel from the active state to the inactive state. As a result, the membrane cannot be repolarized. The binding of aconitine to the channel also leads to the channel to change conformation from the inactive state to the active state at a more negative voltage. In neurons, aconitine increases the permeability of the membrane for sodium ions, resulting in a huge sodium influx in the axon terminal.